They have not won at United’s home ground since a 3-0 league victory in 2014 and drew 0-0 with Ole Gunnar Solskjaer’s side at Anfield just last weekend.
And Klopp insists that his side will have to be at the top of their game to get a result against the high flying Red Devils.
The German said: “We want to win the game, it’s clear. It’s a cup game, the game will be decided that night and we want to win the game. That’s it. That’s how we will make the line-up. We want to go through.
“For that we have to play really well because United is obviously in a good moment and they get all the results they wanted so far. That’s why we have to be ready, 100 per cent.”