Lampard made the surprise decision to include 38-year-old Cech in his 25-man Premier League squad for the season, despite the legendary goalkeeper hanging up his gloves last year.
The Chelsea manager described it as a “no-brainer” – particularly in light of the Covid-19 pandemic.
But ahead of today’s trip to United, Lampard said: “Petr Cech’s not coming. At least not in that capacity.
“We have a clean bill of health apart from Kepa, who has a shoulder issue and won’t travel to Manchester.”
Kepa’s absence comes after Lampard confirmed Mendy is now Chelsea’s official No1.
The Blues look to be implementing another formation change at Old Trafford, with Mason Mount on the bench and captain Cesar Azpilicueta starting alongside Kurt Zouma and Thiago Silva in a back three.
That is the only personnel change from the midweek draw with Sevilla.
Chelsea XI: Mendy, Azpilicueta, Thiago Silva, Zouma, James, Jorginho, Kante, Chilwell, Havertz, Pulisic, Werner
Subs: Rudiger, Abraham, Caballero, Kovacic, Giroud, Mount, Ziyech
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